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KMID : 0854720090290030208
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Korean Journal of Asthma, Allergy and Clinical Immunology
2009 Volume.29 No. 3 p.208 ~ p.211
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A Case of Chronic Urticaria Presenting with Double Primary Malignancies in the Stomach and the Colon
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Lee In-Joung
Kang Hye-Ryun
Kim Joo-Hee
Han Bo-ram
Seo Jin-Won
Park Sung-Hoon
Hwang Yong-Il
Jang Seung-Hoon
Kim Dong-Kyu
Jung Ki-Suck
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Abstract
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Chronic urticaria is a common disabling skin condition. Neoplasm has been case-reported as a comorbid disease with urticaria, although there is no reliable evidence suggesting a strong association between these two conditions. We recently experienced a case of chronic urticaria revealing double primary cancers. A 47-year-old woman was referred to our hospital for chronic generalized urticaria which had started 3 months earlier. She was treated with a combination of oral methylprednisolone, hydroxyzine, mequitazine, fexofenadine, ketotifen, ranitidine, and pranlukast. Nevertheless, her skin lesion did not completely subside. She had a family history of early-onset adenocarcinomas of the stomach and the colon. On gastroscopy and colonoscopy, she was diagnosed with signet ring cell type adenocarcinoma and moderately differentiated adenocarcinoma, respectively. Her urticaria disappeared immediately after radical resection of double primary malignancies, and she became free of urticaria without any medications. Considering the time sequence, malignancies were highly suspicious as a cause of her urticaria.
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KEYWORD
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Urticaria, Neoplasm
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